WHY SINIMET NOT GOOD Enough 5-2-2021 FROM LAPTOP
Many investigators believe that PBM (PHOTOBIOMODULATION) for brain disorders will become one of the most important medical applications of light therapy in the coming years and decades. Despite the efforts of “Big Pharma”, prescription drugs for psychiatric disorders are not generally regarded very highly (either by the medical profession or by the public), and many of these drugs perform little better than placebos in different trials, and moreover can also have major side-effects . Moreover it is well accepted that with the overall aging of … https://www.nbic.nlm.nih.gov/pmc/articles/PMC5066074/
Until our 3-2-20 meeting, I did not know Levadopa and Carbadopa cause sleepiness and that I am taking a “moderate-heavy” amount.
Returned about 12:47 to take my noon pills. Immediately went TO chair and napped for 90 minutes. Woke with my hand shaking.
Could Levadopa and Carbidopa be causing my sleepiness? Taking too much of it? 8 PER DAY.
After taking my 8:00 AM pills I often go back to sleep for 60-90 minutes.
Might L and C pills be reduced by one or two a day to see if that helps reduce my sleepiness?
The use of levodopa and other dopaminergic treatments in progressive PD lessens the risks of dyskinesia (ABNORMAL MOVEMENTS… Dyskinesia is most commonly caused by medications, such as long term use of levodopa in Parkinson’s disease and use of antipsychotic medications. ) and motor fluctuation.[5,6] However, the long-term use of levodopa leads to a loss of efficacy and to complications such as motor fluctuation and dyskinesia. These complications are observed in 50% of patients after 5 years of levodopa use for PD and in 80% of patients after 10 years of levodopa use.[7,8] source? … https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279085/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228622/ 6. Carbidopa/Levodopa Must be Taken on an Empty Stomach
Levodopa is a large neutral amino acid that crosses the blood-brain barrier via a molecular transporter, which selectively binds all amino acids from that class. Obviously, digestion of dietary proteins liberates amino acids into the circulation, and these compete with levodopa for transport across the blood-brain barrier. This transport system is easily saturated, and administration of carbidopa/levodopa with meals substantially reduces efficacy. To ensure that levodopa passage across the blood-brain barrier is not compromised, patients should be advised to take their carbidopa/levodopa doses an hour or more before, and 2 or more hours after eating.
Mayo clinic: What is the best time to take carbidopa levodopa?
Because protein interferes with the absorption of carbidopa-levodopa, take the medication either 30 minutes before or one to two hours after a meal
https://parkinsonsnewstoday.com/2019/01/29/levodopa-shows-no-disease-modifying-effect-in-parkinsons/ Levodopa is the main treatment for Parkinson’s disease. However, neurologists might delay prescribing levodopa for different reasons, including concern about the development of levodopa-induced dyskinesias (abnormal, uncontrolled, involuntary movements), which is one of the most common dose-limiting side effects of this treatment approach.
However, almost all patients eventually receive levodopa to control their motor symptoms.
In an earlier clinical trial, called ELLDOPA , 361 patients with early Parkinson’s disease received levodopa or placebo for 40 weeks. Two weeks after that, clinical examination showed that the participants who had received levodopa had a slower disease progression than those on placebo. However, brain imaging studies revealed that levodopa had either accelerated the death of dopaminergic neurons, or it had modified the protein responsible for the transport of dopamine in brain nerve cells.
“Therefore, whether levodopa has an effect on the progression of Parkinson’s disease beyond its immediate benefit with respect to symptoms remains unknown,” scientists wrote.
…. At week 80, there was no significant difference between the early-start and delayed-start group regarding motor and non-motor symptoms, as measured by the UPDRS, indicating that levodopa had no disease-modifying effect.
Oct 10, 2014 — While Sinemet is the most effective medicine and has the fewest … control disorders, such as excessive gambling, buying, eating, or sex.
People also ask
Should Sinemet be taken on an empty stomach?
Levodopa enters the brain and is converted to dopamine while carbidopa prevents or lessens many of the side effects of levodopa, such as nausea, vomiting, and occasional heart rhythm disturbances. It is generally recommended that patients take Sinemet on an empty stomach, at least ½ hour before or one hour after meals.Oct 10, 2014
The above sources lists a few of the efficacy reasons why I wish you would rewrite the order for the cARELTON’s pill delivery staff so that Sinemet might do less long-term damage and be more effective over its presumed 4-ish hours of usage.
Your (Doctor’s orders) orders might say:
“If the patient requests one pill rather than two, give him one pill.
“If the patient has recently finished a meal and requests that you either come back in an hour or leave the pills, do so… leave them or find patient with pills and water in an hour.”
There are many activities (various meal delivery times, scheduled activities, exercise programs, walking, etc.) that conflict with pill delivery and their efficacy.
National Institute Of Health (NIH), Mayo Clinic, Parkinson’s News Today. Cleveland Clinic.
Read Norman Doidge’s The Brain’s Way of Healing.